Anti–influenza H7 human antibody targets antigenic site in hemagglutinin head domain interface
نویسندگان
چکیده
منابع مشابه
688 ANTIINFLUENZA HEMAGGLUTININ ANTIBODY DIVERSITY secondary
The initial antibody repertoire is determined by multiple heavy and light chain variable region (V. and VL) ~ gene segments and multiple joining gene segments (J~, Jx, JH, and D.). These gene segments can join in various combinations (1-8) and complete V gene products can associate in different combinations. As a result of combinational joining and association, the size of the preimmune reperto...
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The hemagglutinin (HA) of influenza A viruses has been classified into sixteen distinct subtypes (H1-H16) to date. The HA subtypes of influenza A viruses are principally defined as serotypes determined by neutralization or hemagglutination inhibition tests using polyclonal antisera to the respective HA subtypes, which have little cross-reactivity to the other HA subtypes. Thus, it is generally ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2020
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci136032